IDEAS segmentation using both human and mouse. IDEAS does simultaneous two-dimensional modeling along chromosomes and across cell types provides a consistent and well-resolved annotation while, the system leverages epigenetic information from locally related cell types when assigning states in cell types with missing data (Zhang and Mahony 2019). Its Bayesian statistical framework allows the incorporation of epigenetic models from different studies and even species.
Heatmap of emission frequencies and color code for each state:
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Guanjue Xiang, et al. biorxiv