S3V2 normalized read counts for the input into the IDEAS segmentation.
The normalization method S3V2 was designed to match the ranges of both signal intensities and variances across epigenetic datasets. The method adjusts both the non-zero means and the standard deviations of the background regions, so that it can better reduce background noise in some data sets with higher variance at the background regions.
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Guanjue Xiang, et al. biorxiv
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